2025
Bong-Ki Hong , Sungyong You , Jung Gon Kim , Minhyung Kim , Naeun Lee , Kijun Lee , In-Pyo Baek , Ji Hyeon Ju , Wan-Uk Kim , Ho-Youn Kim
Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis
Front Immunol
Jung Gon Kim , Mingyo Kim , Bong-Ki Hong , Yong-Ho Choe , Ju-Ryoung Kim , Naeun Lee , Sungyong You , Sang-Il Lee , Wan-Uk Kim
Circulatory age-associated B cells: Their distinct transcriptomic characteristics and clinical significance in drug-naïve patients with rheumatoid arthritis
Clin Immunol
Howook Jeon , Youngjae Park , Jennifer Jooha Lee , Yoo-Seok Suh , Seung-Ki Kwok , Sung-Hwan Park , Wan-Uk Kim , Jung Hee Koh
The prevalence, clinical features, and long-term outcome of patients with primary Sjögren's syndrome with renal involvement
Multicenter Study
2024
Howook Jeon , Jennifer Lee , Su-Jin Moon , Seung-Ki Kwok , Ji Hyeon Ju , Wan-Uk Kim , Sung-Hwan Park
Predictors of renal relapse in Koreans with lupus nephritis after achieving complete response: a 35-years of experience at a single center
Korean J Intern Med
Hanna Park , Ji Hyun Lee , Seung-Ki Kwok , Ji Hyeon Ju , Wan-Uk Kim , Sung-Hwan Park , Jennifer Jooha Lee
Characteristics of patients with psoriatic arthritis in Korea: focusing on axial involvement
Korean J Intern Med
Serum and urine lipidomic profiles identify biomarkers diagnostic for seropositive and seronegative rheumatoid arthritis
Front Immunol
Drug retention of biologic and targeted synthetic disease-modifying antirheumatic drugs in Korean patients with seropositive rheumatoid arthritis
Korean J Intern Med
The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation
Exp Mol Med
Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis
Immune Netw
Serum amyloid A expression in liver promotes synovial macrophage activation and chronic arthritis via NFAT5
J Clin Invest
Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis
Cell Mol Immunol
Ji Hee Lim , Yaeni Kim , Min Young Kim , Eun Nim Kim , Tae Woo Kim , Bum Soon Choi , Wan-Uk Kim , Hye Won Kim , Ji Yong Park , Cheol Whee Park
Placental growth factor deficiency initiates obesity- and aging-associated metabolic syndrome
Metabolism
Jung Gon Kim , Sunhee Jang , Jennifer Lee , Ji Hyeon Ju , Wan-Uk Kim , Sung-Hwan Park , Seung-Ki Kwok
A single-centre retrospective study of factors affecting steroid-free remission of immunoglobulin G4-related disease conducted in South Korea: A notable outcome after complete resection
Mod Rheumatol
2023
Protective role of colitis in inflammatory arthritis via propionate-
producing Bacteroides in the gut
Front Immunol
Mycobacterium potentiates protection from colorectal cancer by gut microbial alterations
Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses
Arthritis Res Ther
A single-centre retrospective study of factors affecting steroid-free remission of IgG4-related disease conducted in South Korea: a notable outcome after complete resection
Role of high-temperature requirement serine protease A 2 in rheumatoid inflammation
Arthritis Res Ther
Salivary ultrasonography and histopathologic evaluation of secondary Sjögren's syndrome in rheumatoid arthritis patients
Sci Rep
Identification of MYH9 as a key regulator for synoviocyte migration and invasion through secretome profiling
Ann Rheum Dis
Changes in the cholesterol profile of patients with rheumatoid arthritis treated with biologics or Janus kinase inhibitors
J Rheum Dis
2022
Genetic deficiency of nuclear factor of activated T cells 5 attenuates the development of osteoarthritis in mice
8-Shogaol inhibits rheumatoid arthritis through targeting TAK1
Golden Age of Immunotherapy: Challenges and Opportunities
Can whole spine magnetic resonance imaging predict radiographic progression and inflammatory activity in axial spondyloarthritis?
Joint Bone Spine
Jung Hee Koh, Sang Jun Yoon, Mina Kim, Seonghun Cho, Johan Lim, Youngjae Park, Hyun-Sook Kim, Sung Won Kwon, Wan-Uk Kim
Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis
Experimental & Molecular Medicine
Howook Jeon , Jennifer Lee , Ji Hyeon Ju , Wan-Uk Kim ,
Sung-Hwan Park , Su-Jin Moon , Seung-Ki Kwok
Chronic kidney disease in Korean patients with lupus nephritis: over a 35-year period at a single center
A Rare Case of Ankylosing Spondylitis Coexisting with Relapsing Polychondritis, Antiphospholipid Syndrome,
and Myelodysplastic Syndrome
Re-evaluation of the prognostic significance of oropharyngeal dysphagia in idiopathic inflammatory myopathies
Differential effects of periodontal microbiome on the rheumatoid factor induction
during rheumatoid arthritis pathogenesis
Dysbiotic but nonpathogenic shift in the fecal mycobiota of patients with rheumatoid arthritis
Time-integrated Cumulative Parameters Predictive of Radiographic Progression of Rheumatoid Arthritis:
Real-world Data From a Prospective Single-center Cohort
2021
Sang Youn Jung, Jung Hee Koh, Ki-Jo Kim, Yong-Wook Park, Hyung-In Yang, Sung Jae Choi, Jisoo Lee, Chan-Bum Choi, Wan-Uk Kim
Arthritis Res Ther
Switching from TNFα inhibitor to tacrolimus as maintenance therapy in rheumatoid arthritis after achieving low disease activity with TNFα inhibitors and methotrexate: 24-week result from a non-randomized, prospective, active-controlled trial
2020
Jung Hee Koh, Saseong Lee, Hyun-Sook Kim, Kyuheon Lee, Chang Seop Lee, Seung-Ah Yoo, Naeun Lee, Wan-Uk Kim
J Clin Med
Development of Monitoring System for Assessing Rheumatoid Arthritis within 5 Minutes
Using a Drop of Bio-Fluids
Riri Kwon, Bong-Ki Hong, Kang-Gu Lee, Eunbyeol Choi, Laurent Sabbagh, Chul-Soo Cho, Naeun Lee, Wan-Uk Kim
Regulation of tumor growth by leukocyte-specific protein 1 in T cells
J Immunother Cancer
Jin-Sun Kong, Ji-Hwan Park, Seung-Ah Yoo, Ki-Myo Kim, Yeung-Jin Bae, Yune-Jung Park, Chul-Soo Cho, Daehee Hwang, Wan-Uk Kim
Dynamic transcriptome analysis unveils key proresolving factors of chronic inflammatory arthritis
J Clin Invest
Yune-Jung Park, Seung-Ah Yoo, Mingyo Kim, Wan-Uk Kim
The Role of Calcium-Calcineurin-NFAT Signaling Pathway in Health and Autoimmune Diseases
Front Immunol
Ji-Won Kim, Jin-Sun Kong, Saseong Lee, Seung-Ah Yoo, Jung Hee Koh, Jingchun Jin, Wan-Uk Kim
Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis
Exp Mol Med
2019
Seung-Ah Yoo, Chul-Soo Cho, Wan-Uk Kim
Journal of Rheumatic Diseases
Distinct Urinary Metabolic Profile in Rheumatoid Arthritis Patients: A Possible Link
between Diet and Arthritis Phenotype
Seung-Ah Yoo, Mingyo Kim, Min-Cheol Kang, Jin-Sun Kong, Ki-Myo Kim, Saseong Lee, Bong-Ki Hong, Gi Heon Jeong, Jinhee Lee, Min-Gyeong Shin, Yeon-Gu Kim, Ivana Apicella, Valeria Cicatiello, Sandro De Falco, Chong-Hyeon Yoon, Chul-Soo Cho, Zae Young Ryoo, Seung-Hyo Lee, Wan-Uk Kim
Placental growth factor regulates the generation of T H 17 cells to link angiogenesis with autoimmunity
Nat Immunol
Naeun Lee, Donghyun Kim, Wan-Uk Kim
Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases
Front Immunol
2018
Saseong Lee, Jin-Sun Kong, Sungyong You, H. Moo Kwon,Seung-Ah Yoo, Chul-Soo Cho and Wan-Uk Kim
Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2
J Immunol
Sungyong You, Jung Hee Koh, Lin Leng, Wan-Uk Kim, Richard Bucala
The Tumor-Like Phenotype of Rheumatoid Synovium: Molecular Profiling and Prospects for Precision Medicine
Arthritis Rheumatology
2017
Susanna Choi, Sungyong You, Donghyun Kim, Soo Youn Choi, H. Moo Kwon, Hyun-Sook Kim, Daehee Hwang, Yune-Jung Park, Chul-Soo Cho, Wan-Uk Kim
J Clin Invest
Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis
Daehee Hwang, Wan-Uk Kim
Rheumatoid arthritis: Modelling cytokine signalling networks
Nat Rev Rheumatol
Koh JH, Kim WU
Dysregulation of gut microbiota and chronic inflammatory disease: from epithelial defense to host immunity
Exp Mol Med
Lee N, Kim WU
Microbiota in T-cell homeostasis and inflammatory diseases
Exp Mol Med
Han EJ, Kim HY, Lee N, Kim NH, Yoo SA, Kwon HM, Jue DM, Park YJ, Cho CS, De TQ, Jeong DY, Lim HJ, Park WK, Lee GH, Cho H, Kim WU
Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors
EBioMedicine
Hong BK, You S, Yoo SA, Park D, Hwang D, Cho CS, Kim WU
MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis
Exp Mol Med
2016
Seung-Ah Yoo, Lin Leng, Bum-Joon Kim, Xin Du, Pathricia V Tilstam, Kyung Hee Kim, Jin-Sun Kong, Hyung-Ju Yoon, Aihua Liu, Tian Wang, Yan Song, Maor Sauler, Jurgen Bernhagen, Christopher T Ritchlin, Patty Lee, Chul-Soo Cho, Wan-Uk Kim, Richard Bucala
MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis
Proc Natl Acad Sci U S A
Kim D, Kim WU
Editorial: Can Prevotella copri Be a Causative Pathobiont in Rheumatoid Arthritis?
Arthritis Rheumatol
Jung Hee Koh, Michael Joseph Kemna Jan Willem Cohen Tervaert, Wan-Uk Kim
Editorial: Can an Increase in Antineutrophil Cytoplasmic Autoantibody Titer Predict Relapses in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis?
Arthritis Rheumatol
Han EJ, Yoo SA, Kim GM, Hwang D, Cho CS, You S, Kim WU
GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness
J Rheumatol
Park YJ, Yoo SA, Hwang D, Cho CS, Kim WU
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis
Exp Mol Med
Kim D, Yoo SA, Kim WU
Gut microbiota in autoimmunity: potential for clinical applications
Arch Pharm Res
Park YJ, Yoo SA, Kim GR, Cho CS, Kim WU
Urinary interleukin-6 as a predictor of radiographic progression in rheumatoid arthritis: A 3-year evaluation
Sci Rep
2015
Seong-Hye Hwang, Seung-Hyun Jung, Saseong Lee, Susanna Choi, Seung-Ah Yoo, Ji-Hwan Park, Daehee Hwang, Seung Cheol Shim, Laurent Sabbagh, Ki-Jo Kim, Sung Hwan Park, Chul-Soo Cho, Bong-Sung Kim, Lin Leng, Ruth R. Montgomery, Richard Bucala, Yeun-Jun Chung, and Wan-Uk Kim
Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis
Proc Natl Acad Sci U S A
Seung-Ah Yoo, Ji-Hwan Park, Seong-Hye Hwang, Sang-Min Oh, Saseong Lee, Valeria Cicatiello, Sangchul Rho, Sandro De Falco, Daehee Hwang, Chul-Soo Cho, and Wan-Uk Kim
Placental Growth Factor-1 and -2 Induce Hyperplasia and Invasiveness of Primary Rheumatoid Synoviocytes
J Immunol
Sang-Il Lee and Wan-Uk Kim
Dual effects of tumor necrosis factor α inhibitors on septic arthritis: from a "bad friend" to a "good enemy"
Arthritis Rheumatol
Yune-Jung Park, Min Kyung Chung, Daehee Hwang and Wan-Uk Kim
Proteomics in Rheumatoid Arthritis Research
Immune Network
Ki-Jo Kim, Saseong Lee, Wan-Uk Kim
Applications of systems approaches in the study of rheumatic diseases
Korean J Intern Med
2002 ~ 2014
Seung-Ah Yoo, Sungyong You, Hyung-Ju Yoon, Dong-Ho Kim, Hyun-Sook Kim, Kyungho Lee, Jin Hee Ahn, Daehee Hwang, Amy S. Lee, Ki-Jo Kim, Yune-Jung Park, Chul-Soo Cho, and Wan-Uk Kim
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis
The Journal of Experimental Medicine
Sungyong You, Seung-Ah Yoo, Susanna Choi, Ji-Young Kim, Su-Jung Park, Jong Dae Ji, Tae-Hwan Kim, Ki-Jo Kim, Chul-Soo Cho, Daehee Hwang, and Wan-Uk Kim
Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach
Proceedings of the National Academy of Sciences
Seung-Ah Yoo, Hyung-Ju Yoon, Hyun-Sook Kim, Chi-Bom Chae, Sandro De Falco, Chul-Soo Cho, and Wan-Uk Kim
Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: a link between angiogenesis and inflammation
Arthritis Rheum
Hyung-Ju Yoon, Sungyong You, Seung-Ah Yoo, Nam-Hoon Kim, H. Moo Kwon, Chong-Hyeon Yoon, Chul-Soo Cho, Daehee Hwang, and Wan-Uk Kim
NF-AT5 is a critical regulator of inflammatory arthritis
Arthritis Rheum
Jin-Sun Kong, Seung-Ah Yoo, Jung-Wook Kim, Seung-Pil Yang, Chi-Bom Chae,
Valeria Tarallo, Sandro De Falco, Sung-Ho Ryu, Chul-Soo Cho, and Wan-Uk Kim
Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis
Arthritis Rheum
Nam-Hoon Kim, Susanna Choi, Eun-Jin Han, Bong-Ki Hong, Soo Youn Choi, H. Moo Kwon, Sue-Yun Hwang, Chul-Soo Cho, and Wan-Uk Kim
The xanthine oxidase-NFAT5 pathway regulates macrophage activation and TLR-induced inflammatory arthritis
European Journal of Immunology
Sungyong You, Chul-Soo Cho, Inyoul Lee, Leroy Hood, Daehee Hwang, Wan-Uk Kim
A systems approach to rheumatoid arthritis
PLoS One
Ki-Jo Kim, Chul-Soo Cho and Wan-Uk Kim
Role of placenta growth factor in cancer and inflammation
Experimental and Molecular Medicine
Min Jueng Kang, Yune-Jung Park, Sungyong You, Seung-Ah Yoo, Susanna Choi, Dong-Ho Kim, Chul-Soo Cho, Eugene C. Yi, Daehee Hwang, and Wan-Uk Kim
Urinary proteome profile predictive of disease activity in rheumatoid arthritis
J Proteome Res
Nam-Hoon Kim, Bong-Ki Hong, Soo Youn Choi, Hyug Moo Kwon, Chul-Soo Cho, Eugene C Yi and Wan-Uk Kim
Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes
Experimental & Molecular Medicine
Taeyoon Son, Hyung-Ju Yoon, Saseong Lee, Won Seuk Jang, Byungjo Jung, and Wan-Uk Kim
Continuous monitoring of arthritis in animal models using optical imaging modalities
J Biomed Opt
Yune-Jung Park, Seung-Ah Yoo, and Wan-Uk Kim
Role of endoplasmic reticulum stress in rheumatoid arthritis pathogenesis
J Korean Med Sci
Yune-Jung Park, Chul-Soo Cho, Paul Emery, Wan-Uk Kim
LDL Cholesterolemia as a Novel Risk Factor for Radiographic Progression of Rheumatoid Arthritis: A Single-Center Prospective Study
PLoS One
Yune-Jung Park, Seung-Ah Yoo, Susanna Choi, Hee-Soo Yoo, Ho-Sung Yoon, Chul-Soo Cho, Ki-Dong Yoo, and Wan-Uk Kim
Association of polymorphisms modulating low-density lipoprotein cholesterol with susceptibility, severity, and progression of rheumatoid arthritis
J Rheumatol
The APOM polymorphism as a novel risk factor for dyslipidaemia in rheumatoid arthritis: a possible shared link between disease susceptibility and dyslipidaemia
Clinical & Experimental Rheumatology
Susanna Choi, Hang-Rae Kim, Lin Leng, Insoo Kang, William L. Jorgensen, Chul-Soo Cho, Richard Bucala, and Wan-Uk Kim
Role of macrophage migration inhibitory factor in the regulatory T cell response of tumor-bearing mice
J Immunol
Jun-Koo Yi, Hei-Jung Kim, Dong-Hoon Yu, Seo-Jin Park, Mi-Jung Shin, Hyung-Soo Yuh, Ki-Beom Bae, Young-Rae Ji, Na-Ri Kim, Si-Jun Park, Jae-Young Kim, Hyun-Shik Lee, Sang-Gyu Lee, Du Hak Yoon, Byung-Hwa Hyun, Wan-Uk Kim, and Zae-Young Ryoo
Regulation of inflammatory responses and fibroblast-like synoviocyte apoptosis by calcineurin-binding protein 1 in mice with collagen-induced arthritis
Arthritis Rheum
Jin-Sun Kong, Seung-Ah Yoo, Jong-Hoon Kang, Wooree Ko, Sangmin Jeon, Chi-Bom Chae, Chul-Soo Cho, Wan-Uk Kim
Suppression of neovascularization and experimental arthritis by D-form of anti-flt-1 peptide conjugated with mini-PEG(™)
Angiogenesis
Jin-Sun Kong, Seung-Ah Yoo, Hyun-Sook Kim, Hyun Ah Kim, Kyungmoo Yea, Sung-Ho Ryu, Yeun-Jun Chung, Chul-Soo Cho, and Wan-Uk Kim
Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate
Arthritis Rheum
Wan-Uk Kim, Antoine Sreih, and Richard Bucala
Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention
Autoimmun Rev
Kim HS, Kim CH, Park YH, Kim Wan-Uk
18Fluorine fluorodeoxyglucose-positron emission tomography/computed tomography in dermatomyositis
Joint Bone Spine
Proinflammatory Role of Vascular Endothelial Growth Factor in the Pathogenesis of Rheumatoid Arthritis: Prospects for Therapeutic Intervention
Mediators Of Inflammation
Seung-Ah Yoo, Bo-Hyoung Park, Hyung-Ju Yoon, Joo-Yup Lee, Joo-Hyoun Song, Hyun Ah Kim, Chul-Soo Cho, Wan-Uk Kim
Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritis
Arthritis Rheum
Soluble Fas ligand inhibits angiogenesis in rheumatoid arthritis
Arthritis Res Ther
Wan-Uk Kim, Soon Suk Kang, Seung-Ah Yoo, Kyung-Hee Hong, Dong-Goo Bae, Mi-Sook Lee, Seung Woo Hong, Chi-Bom Chae, Chul-Soo Cho
Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation
J Immunol
Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis
J Immunol
Seung-Ah Yoo, Bo-Hyoung Park, Gyeong-Sin Park, Hae-Seok Koh, Mi-Sook Lee, Sung Ho Ryu, Keiji Miyazawa, Sung-Hwan Park, Chul-Soo Cho, Wan-Uk Kim
Calcineurin is expressed and plays a critical role in inflammatory arthritis
J Immunol
Seung-Ah Yoo, Dong-Goo Bae, Jae-Woong Ryoo, Hae-Rim Kim, Gyeong-Sin Park, Chul-Soo Cho, Chi-Bom Chae, Wan-Uk Kim
Arginine-Rich Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Hexapeptide Inhibits Collagen-Induced Arthritis and VEGF-Stimulated Productions of TNF-α and IL-6 by Human Monocytes
J Immunol
T Cell Proliferative Response to Type II Collagen in the Inflammatory Process and Joint Damage in Patients with Rheumatoid Arthritis
J Rheumatol
Elevated matrix metalloproteinase-9 in patients with systemic sclerosis
Arthritis Res Ther
So-Youn Min, Sue-Yun Hwang, Young-Ok Jung, Jinyoung Jeong, Sung-Hwan Park, Chul-Soo Cho, Ho-Youn Kim, Wan-Uk Kim
Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes
J Rheumatol